Journal of Family and Community Medicine

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 23  |  Issue : 2  |  Page : 88--93

Proportion and determinants of tuberculosis among human immunodeficiency virus-positive patients attending the antiretroviral therapy center attached to a Medical College in South India


Vandana Hiregoudar1, Bellara Raghavendra2, Aravind Karinagannavar3, Wahid Khan2, Sneha Kamble2, Timmalapur G Goud2 
1 Department of Community Medicine, SDMCMS and Hospital, Sattur, Dharwad, India
2 Department of Community Medicine, VIMS, Bellary, Karnataka, India
3 Department of Community Medicine, MIMS, Mysore, Karnataka, India

Correspondence Address:
Vandana Hiregoudar
Department of Community Medicine, SDMCMS and Hospital, Manjushree Nagar, Sattur, Dharwad - 580 009, Karnataka
India

Background: The human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) pandemic has caused a re-emergence of tuberculosis (TB). In persons infected with both HIV and TB, the lifetime risk of developing TB disease is 50–70% compared to 10% in HIV-negative individuals. India has world's 3rd highest HIV burden and is also one of the countries endemic for TB, so the country faces a dual epidemic of HIV and TB. Objectives: To find out the proportion and determinants of TB in HIV-positive subjects. Subjects and Methods: This study was undertaken at the ART center from June 01, 2012, to May 31, 2013. HIV-positive subjects aged above 15 years who had been on antiretroviral therapy (ART) for more than 6 months were included in the study. Nonprobability purposive sampling was adopted. A predesigned semi-structured questionnaire was used to obtain data. Results: A total of 536 HIV-positive people were interviewed, 58.8% of whom were males, 79.1% were Hindu, 61.0% had up to high school education, and 57% were unskilled laborers. About 63% were married, 40% were from the upper lower class, and 60% were from urban areas. For the majority (89.1%), the probable mode of transmission of HIV was by the heterosexual route. TB co-infection was present in 38.4% subjects. The most common form of TB was extra-pulmonary in subjects on antituberculous treatment (47.3%) and among old cases (57.6%). On bivariate analysis, 136 (42.4%) married subjects and those from rural areas were more commonly affected by TB compared to subjects who were unmarried and from urban areas with odds ratio (OR): 1.555, confidence interval (CI): 1.077–2.246 and OR: 1.523, CI: 1.061–2.185, respectively. The proportion of TB was high among subjects who lived in overcrowded houses 130 (44.2%), and who had a habit of alcohol use compared to others with OR: 1.731, CI: 1.734–2.179 and OR: 1.524, CI: 1.045–2.223, respectively. Logistic regression analysis showed that TB among people living with HIV/AIDS was highest in persons living in overcrowded houses (OR: 1.706, CI: 1.185–2.458) and those who consumed alcohol (OR: 1.605, CI: 1.090–2.362). Conclusions: Demographic factors like male gender, middle age, living in the rural areas, consumption of alcohol, and living in overcrowded houses were found with a higher proportion of TB. The use of highly active ART appeared to progressively decrease but did not completely eliminate the risk of TB.


How to cite this article:
Hiregoudar V, Raghavendra B, Karinagannavar A, Khan W, Kamble S, Goud TG. Proportion and determinants of tuberculosis among human immunodeficiency virus-positive patients attending the antiretroviral therapy center attached to a Medical College in South India.J Fam Community Med 2016;23:88-93


How to cite this URL:
Hiregoudar V, Raghavendra B, Karinagannavar A, Khan W, Kamble S, Goud TG. Proportion and determinants of tuberculosis among human immunodeficiency virus-positive patients attending the antiretroviral therapy center attached to a Medical College in South India. J Fam Community Med [serial online] 2016 [cited 2022 Jan 27 ];23:88-93
Available from: https://www.jfcmonline.com/article.asp?issn=2230-8229;year=2016;volume=23;issue=2;spage=88;epage=93;aulast=Hiregoudar;type=0