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Year : 2015  |  Volume : 22  |  Issue : 2  |  Page : 88-95

Nigella sativa: A potential natural protective agent against cardiac dysfunction in patients with type 2 diabetes mellitus

1 Department of Physiology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia
2 Department of Medicine, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia
3 Department of Family Medicine, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia

Correspondence Address:
Dr. Abdullah Bamosa
Department of Physiology, College of Medicine, University of Dammam, Dammam
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8229.155380

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Objectives: To study the effect of Nigella sativa supplementation on cardiac functions in Type 2 diabetic patients treated with oral hypoglycemic agents. Background: Diabetes mellitus is associated with a high risk of cardiovascular morbidity and mortality. A number of reported beneficial effects of N. sativa on cardiovascular function were the inspiration for this study. Materials and Methods: Sixty patients with uncontrolled diabetes (hemoglobin A 1c [HbA 1c ] >7%) and with no known cardiovascular complications were recruited from the outpatient diabetes clinic. They were assigned, by convenience, to two groups; the control group received activated charcoal as placebo while the test group received 2 g/day of powdered N. sativa for 1-year. All patients continued with their standard oral hypoglycemic agents. Echocardiography was used to evaluate the diastolic function, systolic function, and left ventricular mass (LVM) before the intervention and after 6 and 12 months of the treatment. Results: HbA 1c decreased significantly in the N. sativa group but did not change in the control group. Echocardiographic assessment in the control group showed impairment in diastolic function after 12 months, but there were no significant changes in fractional shortening (FS) or ejection fraction (EF). Furthermore, left ventricular (LV) dimensions at diastole and systole, LVM, and LVM index were significantly increased. In N. sativa group, no significant changes were found in diastolic function or LVM. LV dimension at systole was decreased while FS and EF were significantly increased after 6 and 12 months. Conclusion: N. sativa supplementation may protect the hearts of type 2 diabetic patients from diastolic dysfunction while improving LV systolic function.

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Journal of Family and Community Medicine | Published by Wolters Kluwer - Medknow
Online since 05th September, 2010