Journal of Family & Community Medicine
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contact us Login 
 

Users Online: 100 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

 
ORIGINAL ARTICLE
Year : 2012  |  Volume : 19  |  Issue : 3  |  Page : 178-183

Effect of antiretroviral therapy on clinical and immunologic disease progression in HIV positive children: One-year follow-up study


1 Pediatrics Department, Government Medical College, Surat, India
2 Community Medicine Department, P D U Medical College, Rajkot, India
3 Microbiology Department, M P Shah Medical College, Jamnagar, India

Correspondence Address:
Rajesh K Chudasama
"Vandana Embroidery," Matoshree Complex, Sardar Nagar Main Road, Rajkot- 360 001, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8229.102318

Rights and Permissions

Objective: To study the effect of antiretroviral therapy (ART) on clinical, immunologic, and nutritional progression of disease in human immunodeficiency virus (HIV)-infected children for 1 year. Materials and Methods: The study included 54 children aged 1.5-15 years who registered at the ART center, Surat, from August 2007 to August 2009. During the study period, the children were followed-up at 6 monthly intervals up to 1 year after starting ART. World Health Organization (WHO) clinical staging and CD4 cell count as per national guidelines, and nutritional status were used to measure clinical and immunologic progression of disease up to 1 year. Results: Out of 54 children, mother-to-child transmission was reported in 96.2% children; for 74% of the children, both parents were HIV positive. All the children were classified according to WHO clinical staging into 4 stages and as per CD4 cell count (%), followed up at 6 and 12 months and the benefits with ART reported. At 12 months follow-up, 15% of the study group children had died. Both mean CD4 count and a relative percentage showed significant increase (P < 0.01) in the study group 1 year after ART. Conclusion: The present study reports benefits of ART in terms of clinical and immunologic progression of disease, nutritional status of HIV-infected children after 1 year of ART.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3914    
    Printed164    
    Emailed0    
    PDF Downloaded2530    
    Comments [Add]    
    Cited by others 2    

Recommend this journal

 

Advertise | Sitemap | What's New | Feedback | Disclaimer
Journal of Family and Community Medicine | Published by Wolters Kluwer - Medknow
Online since 05th September, 2010