Journal of Family and Community Medicine

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 21  |  Issue : 1  |  Page : 13--16

Consanguinity pattern and heritability of Vitiligo in Arar, Saudi Arabia


Dhaifallah A Alenizi 
 Department of Dermatology, College of Medicine, Northern Borders University, Arar, Saudi Arabia

Correspondence Address:
Dhaifallah A Alenizi
P.O. Box 334, Arar 91411
Saudi Arabia

Context: Epidemiological studies have shown that vitiligo is a complex trait, involving combinations of pathogenic effects of multiple susceptibility genes as well as environmental risk factors. Aim: To observe whether consanguinity increased the incidence of vitiligo in Saudi patients from Arar. Patients and Methods: This study included 69 Saudi patients with vitiligo and their families. These patients, selected from the experience specialist dermatology center in Arar, from April 2011 to 2012, were interviewed by a dermatologist to confirm the diagnosis and complete a questionnaire. Results: A total of 69 patients, 40 males and 29 females were selected. Their mean age was 34.5 ± 11.8 years with the median age of 23 years. The mean age at onset of disease was 27.9 ± 12.9 years. The mean duration of the disease was 9.7 ± 5.3 years. The frequency of focal, vulgaris, universal, and acrofacial subtypes was 22 (31.9%), 21 (30.4%), 8 (11.6%), and 18 (26.1%), respectively. A positive family history of vitiligo was obtained in 45 (65.2%) cases. A comparison of the frequency of vitiligo among siblings in relation to the general population was more in accord with the multifactorial model. Conclusion: Consanguinity in marriage increases the incidence of the disease. Therefore, genetic counseling and premarital examination would be important contributions to lower the prevalence of vitiligo.


How to cite this article:
Alenizi DA. Consanguinity pattern and heritability of Vitiligo in Arar, Saudi Arabia.J Fam Community Med 2014;21:13-16


How to cite this URL:
Alenizi DA. Consanguinity pattern and heritability of Vitiligo in Arar, Saudi Arabia. J Fam Community Med [serial online] 2014 [cited 2020 Aug 12 ];21:13-16
Available from: http://www.jfcmonline.com/article.asp?issn=2230-8229;year=2014;volume=21;issue=1;spage=13;epage=16;aulast=Alenizi;type=0