|Year : 2016 | Volume
| Issue : 1 | Page : 1-5
Control of type 2 diabetes in King Abdulaziz Housing City (Iskan) population, Saudi Arabia
Thamer A Alsulaiman1, Hejab A Al-Ajmi1, Saeed M Al-Qahtani1, Intisar M Fadlallah1, Nashwa E Nawar1, Reem E Shukerallah1, Sadaf R Nadeem1, Nora M Al-weheedy1, Khalid A Al-sulaiman2, Adel A Hassan1, Ayman A Shahin1, Tamer M Kolib1
1 Department of Family Medicine, Iskan Clinics, NGHA, Riyadh, Kingdom of Saudi Arabia
2 Department of Pharmaceutical Care, NGHA, Riyadh, Kingdom of Saudi Arabia
|Date of Web Publication||21-Dec-2015|
Thamer A Alsulaiman
Department of Family Medicine, Iskan Clinics, NGHA, P.O. Box 75301, Riyadh 11415
Kingdom of Saudi Arabia
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Objective: To assess the level of control and prevalence of type 2 diabetes in King Abdulaziz Housing City (Iskan) population of Saudi Arabia. Materials and Methods: Retrospective cross-sectional study conducted in a primary-care setting. All Type 2 diabetics referred to our diabetes center between January 2011 and January 2015 were identified, and their computerized records reviewed. Glycated hemoglobin levels (HbA1c), low-density lipoprotein (LDL), blood pressure (BP), and the albumin-creatinine ratio (ACR) were noted and the patients categorized accordingly. Demographic data (age and gender) were also documented. Inactive patients (not seen for more than 2 years) were excluded. Results: The overall prevalence of type 2 diabetes for all age groups in ISKAN population was 3.25%. About 56% of the diabetics were female and 70% were aged between 18 and 59 years. The rate of uncontrolled diabetes was 59.3%. Males were more likely to have uncontrolled diabetes (odds ratio: 1.44, CI: 1.17-1.76, P = 0.0004). Forty percent of the diabetics had an LDL above target (≥2.6 mmol/l) while 25.9% had uncontrolled hypertension (BP ≥ 140/90 mmHg). Of those who had an ACR test done within the last year (59.3%), the rate of micro- and macro-albuminuria was 8.8% and 2.5%, respectively. Conclusions: The overall prevalence of type 2 diabetes in our community seems lower than the previously reported national figures. An alarming number of diabetics in our population have an uncontrolled disease. More stringent diabetes annual review and recall program is needed to control diabetes and reduce complications.
Keywords: Diabetes, glycemic control, prevalence, Saudi Arabia
|How to cite this article:|
Alsulaiman TA, Al-Ajmi HA, Al-Qahtani SM, Fadlallah IM, Nawar NE, Shukerallah RE, Nadeem SR, Al-weheedy NM, Al-sulaiman KA, Hassan AA, Shahin AA, Kolib TM. Control of type 2 diabetes in King Abdulaziz Housing City (Iskan) population, Saudi Arabia. J Fam Community Med 2016;23:1-5
|How to cite this URL:|
Alsulaiman TA, Al-Ajmi HA, Al-Qahtani SM, Fadlallah IM, Nawar NE, Shukerallah RE, Nadeem SR, Al-weheedy NM, Al-sulaiman KA, Hassan AA, Shahin AA, Kolib TM. Control of type 2 diabetes in King Abdulaziz Housing City (Iskan) population, Saudi Arabia. J Fam Community Med [serial online] 2016 [cited 2020 Jan 19];23:1-5. Available from: http://www.jfcmonline.com/text.asp?2016/23/1/1/172221
| Introduction|| |
Diabetes mellitus is a worldwide chronic condition and a health burden. , The prevalence of diabetes mellitus in Saudi Arabia has been previously estimated around 23.7% in the adult population, which ranks it as one of the countries in the region with the highest prevalence of this condition. , The management of diabetes mellitus can be challenging and requires a multidisciplinary team approach. , This involves glycemic control, as well as management of co-existing risk factors, such as hypertension and dyslipidemia in order to reduce complications. ,, A diabetic annual review can be done to assess the control of diabetics and complications. The review would include the measurement of glycated hemoglobin (HbA1c), albumin creatinine ratio (ACR), fasting lipids (including low-density lipoprotein [LDL]), blood pressure (BP), retinal screening, and a podiatrist assessment.  HbA1c reflects glycemic control over several months and is an indicator of the complications of diabetes.  Good glycemic control is known to delay the onset of diabetic microvascular complications.  Persistent albuminuria is a marker for predicting nephropathy in type II diabetics, and the measurement of ACR is one tool for assessment. ,,, Diabetic patients are at increased risk of cardiovascular disease (CVD), and diabetes is an independent risk factor.  Therefore, monitoring and management of LDL, as well as BP, is recommended as this reduces CVD risk and renal injury. ,,, Annual dilated, and comprehensive eye examination is recommended to look for retinopathy, a frequent cause of new cases of blindness in adults.  Moreover, an annual check by a podiatrist is essential as it involves assessment for neuropathy and ulcerations, which contribute to more than 80% of amputations in diabetics. 
King Abdul-Aziz Housing City (ISKAN) is one of the National Guard housing compounds located in the Saudi Capital, Riyadh. Its population is about 53,160 of eligible residents who are mainly officers or soldiers and their dependents. The housing area is served by 11 primary care (satellite) clinics as well as a diabetes center, which accepts referrals for newly diagnosed and uncontrolled type 2 diabetics. The aim of our study was to assess the level of control of type 2 diabetics using measurable parameters (HbA1C, LDL, BP, and ACR) as well as to describe their demographics, and estimate the prevalence of type 2 diabetes in the above population.
| Materials and Methods|| |
All type 2 diabetics referred from primary care clinics within ISKAN to the diabetes center since its opening in 2011 were identified through the logbook of the diabetes center and their computerized records were reviewed. HbA1c levels, LDL, BP, and ACR were noted and patients were categorized accordingly . Three HbA1c groups were compared (HbA1c equal or below 7 mmol/l, HbA1c between 7 and 8, and HbA1c of 8 mmol/l and above) as well as two BP groups (BP below 140/90 and BP equal or above 140/90 mmHg). Levels of LDL above or below 2.6 mmol/l and the presence of micro- or macro-albuminuria were also documented. The American Diabetes Association (ADA) and Eighth Joint National Committee (JNC-8) guidelines were used to set the above targets. Micro-albuminuria was defined as an ACR between 2.5 and 29 mg/mmol for males, and 3.5-29 mg/mmol for females while macroalbuminuria was defined as an ACR above 30 mg/mmol (300 mg/l). Demographic data were noted and the prevalence rate of type 2 diabetes in the ISKAN population was estimated by dividing the total number of type 2 diabetics over the Iskan population. Inactive patients (i.e., not seen for more than 2-years) were excluded from assessment but were included in calculating the prevalence.
| Results|| |
Type-two diabetics referred and seen at our diabetes center between January 2011 and January 2015 were 1733. Of this number, 1632 (94.2%) were active patients and were included in our study. The overall prevalence of type 2 diabetes in the ISKAN population was 3.25% (1733 cases: 53,160 population). Of our studied diabetics, 55.5% were females and 70% were aged between 18 and 59 years [Table 1].
|Table 1: Demographics of active diabetics in an ISKAN population (n=1632) |
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The rate of uncontrolled diabetes (HbA1c ≥ 8 mmol/l) among the type 2 diabetics was 59.3%. Males were more likely to have uncontrolled diabetes (odds ratio: 1.44, CI: 1.18-1.76, P = 0.0004). However, age, LDL, and BP did not have a statistically significant association with uncontrolled diabetes [Table 2]. Forty percent of diabetics had an LDL above target (≥2.6 mmol/l) while 25.9% had uncontrolled hypertension (BP ≥ 140/90 mmHg) [Figure 1].
|Figure 1: Level of diabetes control (glycated hemoglobin, low-density lipoprotein, and blood pressure) in active diabetics in the ISKAN population ( n = 1632). Uncontrolled glycated hemoglobin defined as ≥8 mmol/l, Uncontrolled low-density lipoprotein defined as ≥2.6 mmol/l, and Uncontrolled blood pressure defined as ≥140/90 mmhg|
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In the 12 months preceding our study, (January 2014-January 2015) 59.3% of diabetics had an ACR test done. Of this number, 8.8% had micro-albuminuria and 2.5% macro-albuminuria.
| Discussion|| |
The huge burden of diabetes is putting a strain on health systems worldwide. ,, Uncontrolled diabetics are at a much higher risk of complications such as retinopathy, nephropathy, neuropathy, and CVD. ,,, Various treatment targets have been set to help guide the physician in managing his diabetic patients and monitoring their diabetes control. ,,,, Ideally, control of diabetes involves managing an HbA1c level under or close to 7 mmol/l. ,,, However, such glycemic control may not be achievable for some diabetics. , A higher HbA1c (8 mmol/l) might be acceptable for certain groups such as the elderly with short life expectancy, frail diabetics with multiple co-morbidities and those with a history of severe hypoglycemia.  An HbA1c above eight is generally accepted as being uncontrolled diabetes and is associated with a higher rate of diabetic complications. ,, Raised LDL is a major factor in the pathogenesis of atherosclerosis and CVD.  The ADA recommends keeping the LDL of diabetics below 2.6 mmol/l if there is no known history of CVD and below 1.8 mmol/l if CVD is present. ,,, The guidelines for managing hypertension in diabetics have evolved with higher targets now being accepted. ,,,, A BP of <140/90 mmHg is recommended by the JNC8 for diabetics.  Lower BP targets (<130/80 mmHg) are desired for diabetics with nephropathy and if tolerated, by younger diabetics. ,,
In our study, an HbA1c level of 8 mmol/l or above was used to define uncontrolled diabetes. A higher target but perhaps a more realistic one in identifying uncontrolled diabetics requiring immediate action. Despite our higher threshold, the rate of uncontrolled diabetes in our population was 59.3% while only 18.5% had "good control of diabetes" (HbA1c ≤7%). A study by Zhaolan et al., found that 63% of their studied population had poorly controlled diabetes (A1c >7.5%) while only 12.1% met an optimum HbA1c target (<6.5%).  Another study by Al-Rowais, in Riyadh, found that the rate of "unacceptable HbA1c" for diabetics attending a university hospital was about 60% (HbA1c >7%), while 36% had an HbA1c above 8%.  The rate of uncontrolled diabetics (HbA1c >7%) in a Jordanian study by Khattab et al., was about 65%.  Several factors including patient's compliance and understanding of the disease, literacy and treatment strategy by physicians contribute to the lack of control. 
In our studied population, two important factors affected the patients' compliance: Access to satellite clinics and patient beliefs and educational level. Residents of the housing complex can register their extended families (parents), who live outside the housing complex and sometimes outside Riyadh City. The visits of this group of patients to the clinics are infrequent, leading to a sporadic monitoring of their condition and an improper adjustment of their medications. Moreover, the majority of residents at the ISKAN housing complex come from a moderate educational background, have rigid cultural beliefs and misconceptions about illness and a fear of escalation of treatment (especially initiation of insulin). This in turn, can delay appropriate management, and control of diabetes.
We found that about 40% of our diabetics had dyslipidemia with an LDL level of 2.6 mmol/l or above, an added cardiovascular risk factor for our diabetics. This could have been due to insufficient titration of statin therapy, as well as noncompliance and an intermittent use of statins. Other national institutes have reported a hyper-cholesterolemia rate of 29% among their diabetics, though an LDL test was not done for many.  About three quarters (74.1%) of our diabetics had BP within the recommended target (<140/90 mmHg).  Although the result is promising, it perhaps reflects the application of the newer guidelines in our study and the fact that some diabetics did not have co-existing hypertension.
We investigated whether our diabetics had an ACR test within the last 12 months (prior to the conduct of our study) and examined whether albuminuria, a sign of early kidney disease, was present.  For those who had the test, 8.8% had micro-albuminuria and 2.5% had macroalbuminuria, while a large number (40.7%) had not had the test done. Chavan et al. looked at the rate of albuminuria among diabetics and found the rates of micro-albuminuria and macroalbuminuria as 62.2% and 15.9% respectively.  Some patients find doing a urine test inconvenient while others do not appreciate the reason for doing it. Apart from this, doctors do not always remember to ask for the urine test since the request is made on a separate request form.
Type 2 diabetes was more prevalent in 18-59 age group at a rate of 70%, which compares well with other national studies. For example, Al-Rowais who looked at 1520 diabetics, found that 59.2% were under the age of 60.  In Al-Nozha et al. survey of 4004 diabetics, 75.9% of them were aged between 30 and 59 years. 
Our study reports the overall prevalence of 1733 type 2 diabetics, which corresponds to a rate of 3.25% in the "ISKAN" population with a catchment area of 53,160 eligible residents. In Saudi Arabia, although the previously reported prevalence of diabetes mellitus was ~20-30%, , differences in methodology account for variation in results. For example, the reported rate of 23.7% in Al-Nozha's study, a survey of an age specific group (30-70 years), was of subjects from households in primary care catchment areas, utilizing fasting blood glucose as per the 1997 ADA guidelines.  Several studies have used that figure in their reports. ,, In our study, we calculated the overall prevalence of "type 2 diabetes" for "all age groups" in a local community. ADA 2010 guidelines were applied in our study period, utilizing HbA1c to diagnose diabetes. The estimated figures from the World Health Organization (WHO) on diabetics in Saudi Arabia in 2000 was about 890,000 cases with a projection to over 2,500,000 in 2030.  Bearing in mind that the Saudi Arabia's population was about 22 million in 2000, and rose to almost 31 million in 2014,  the calculated overall prevalence in Saudi Arabia would have been ~4% in 2000, and about 8% in 2014 - using the 2030 estimate. In a study done by Wild et al., that looked at the global prevalence of diabetes "for all age groups", the prevalence was found to be 2.8% in the year 2000 with a projection of 4.4% in 2030. 
Interventions that target follow-up arrangements have been known to improve diabetic outcomes.  A register-recall system to follow-up uncontrolled diabetics can, therefore, be valuable. Such a system could be an important tool for providing structured care for diabetics and in identifying and recalling patients who do not meet the recommended targets.  Primary prevention programs that target prediabetics (promoting healthy diet, exercise, and weight reduction) and patient education programs are also an integral part of reducing the prevalence rate of diabetes.
In our study, we reported diabetics referred to our local diabetes center from primary care clinics. Despite efforts to promote diabetic referrals, a number of diabetics who should have been referred, were not referred to our clinic. This may have resulted in an under-estimation of our reported prevalence. With the relatively large population size at ISKAN (53,160), we estimate that our result might be skewed by 1-2% and the actual overall prevalence in our ISKAN community lies between (3.25% and 5.25%). Moreover, our reported rate reflects the overall prevalence of diabetes in a specific community "ISKAN" with its own characteristics (mainly soldiers with multiple younger siblings). Therefore, applying that rate on a national level may be biased.
| Conclusions|| |
Although the prevalence of type 2 diabetes seems lower than the previously reported national figures - due to methodological differences, the number of people with uncontrolled diabetes in our population is alarming. Recalling uncontrolled diabetics and a more stringent annual review program are needed to control diabetes and reduce long-term complications. Patient education programs are also essential to improve compliance and clarify misconceptions.
We would like to acknowledge the Family Medicine Department, NGHA as well as KAIMRC and the Diabetes Center's staff at ISKAN for their support during this project.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
American Diabetes Association. Standards of medical care in diabetes-2014. Diabetes Care 2014;37:14-62.
Del Prato S, Felton A, Munro N, Nesto R, Zimmet P, Zinman B. Improving glucose management: Ten steps to get more patients with type 2 diabetes to glycemic goal. Recommendations from the global partnership for effective diabetes management. Int J Clin Pract 2005;59:47-57.
Al-Nozha MM, Al-Maatouq MA, Al-Mazrou YY, Al-Harthi SS, Arafah MR, Khalil MZ, et al.
Diabetes mellitus in Saudi Arabia. Saudi Med J 2004;25:1603-10.
Moore P. Improving glycemic control in people with type 2 diabetes: Expanding the primary care toolbox. Best Pract J 2013;53:6-15.
Fowler MJ. Micorvascular and macrovascular complications of diabetes. Clin Diabetes 2008;28:77-82.
The University of York. Complications of diabetes; screening for retinopathy and management of foot ulcers. Eff Health Care 1999;5:1-8.
Nair M. Diabetes mellitus, part 1: Physiology and complications. Br J Nurs 2007;16:184-8.
Chavan V, Ramavataram D, Miyani K, Lad H, Nilakhe S. Prevalance of microalbuminria as a marker of incipient nephropathy in type 2 diabetes patients at Semimer hospital, Surat. Natl J Community Med 2014;5:468-74.
Basi S, Fesler P, Mimran A, Lewis JB. Microalbuminuria in type 2 diabetes and hypertension: A marker, treatment target, or innocent bystander? Diabetes Care 2008;31 Suppl 2:S194-201.
Ben Hamed S, Pavkvic P, Metelko Z. Micoralbuminuria and diabetes mellitus. Diabetol Croat 2002;31:209-21.
Liu Z, Fu C, Wang W, Xu B. Prevalence of chronic complications of type 2 diabetes mellitus in outpatients - A cross-sectional hospital based survey in urban China. Health Qual Life Outcomes 2010;8:62.
New Zealand Guidelines Group. Management of Type-2 Diabetes; 2011. Available from: http://www.health.govt.nz
. [Last accessed on 2015 Feb 10].
Alva M, Gray A, Mihaylova B, Leal J, Holmanet R. The impact of diabetes related complications on healthcare costs: New results from the UKPDS. Diabet Med 2014;32:1-8.
Badran M, Laher I. Type II diabetes mellitus in Arabic-speaking countries. Int J Endocrinol 2012;2012:902873.
Stone NJ, Robinson J, Lichtenstein A, Merz N, Blum C, Eckel R, et al
. ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults. Circulation 2013;129:1-45.
Haffner S. Treating diabetic dyslipidemia: A review of practical recommendations based on clinical trials. Hosp Physician 2006;2006:27-34.
Solano M, Goldberg R. Lipid management in type 2 diabetes. Clin Diabetes 2006;24:27-32.
James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al.
2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507-20.
Arguuedas J. Blood pressure targets for hypertension in people with diabetes mellitus. Cochrane Database Syst Rev 2013;10:1-45.
ACCORD Study Group, Cushman WC, Evans GW, Byington RP, Goff DC Jr, Grimm RH Jr, et al.
Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 2010;362:1575-85.
UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and micorvascular complications in type 2 diabetes: UKPDS38. Br Med J 1998;317:703-13.
Al Qurashi KH, Al Jabri KH, Bokhari S. Prevalence of diabetes mellitus in a Saudi community. Ann Saudi Med 2011;31:19-23.
Majeed A, El-Sayed A, Khoja T, Alshamsan R, Millet CH, Rawaf S. Diabetes in the middle east and north Africa: An update. Diabetes Res Clin Pract 2014;103:218-22.
Alhyas L, Mckay A, Balasanthiran A, Majeed A. Prevalence of type 2 diabetes in the states of the co-operation council for the Arab states of the gulf: A systemaic review. PLoS One 2012;7:1-8.
Wild S, Rojlic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-53.
Al-Rowais N. Glycemic control in diabetic patients in King Khalid university hospital- Riyadh-Saudi Arabia. Saudi Pharm J 2014;22:203-6.
Khattab M, Khader YS, Al-Khawaldeh A, Ajlouni K. Factors associated with poor glycemic control among patients with type 2 diabetes. J Diabetes Complications 2010;24:84-9.
Moorthi C, Paul R, Saravanan B, Senthilkumar N, Sethilkumar C. Factors contribute to uncontrolled diabetes in diabetic population. Res J Pharm Biol Chem Sci 2011;2:170-84.
Renders CM, Valk GD, Griffin SJ, Wagner EH, Eijk Van JT, Assendelft WJ. Interventions to improve the management of diabetes in primary care, outpatient, and community settings: A systematic review. Diabetes Care 2001;24:1821-33.
Georgiou A, Burns J, Penn D, Infante F, Harris M. Register-recall systems: Tools for chronic disease management in general practice. Health Inf Manag 2004;33:31-5.
[Table 1], [Table 2]
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