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LEADING ARTICLE
Year : 1997  |  Volume : 4  |  Issue : 1  |  Page : 57-61

Glanzmann's thrombasthenia-spectrum of clinical presentation on Saudi patients in the eastern province


1 Department of Hematology, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia
2 Department of Orthopaedics, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia
3 Department of Paediatrics, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia

Correspondence Address:
Abdullah AI-Othman
P.O. Box 2845, Al-Khobar 31952
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


PMID: 23008567

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Introduction : Glanzmann's thrombasthenia is a rare inherited hemorrhagic disorder characterized by abnormal platelet function. It usually presents with subcutaneous bleeding and bleeding from the mucous membranes. Objectives : The aim of the study is to find out the clinical presentation of Glanzmann's thrombosthenia in Saudi patients, Eastern Province. Methods: In this report we have reviewed the clinical presentation of sixteen Saudi patients suffering from this disorder presented at King Fahd Hospital of the University in AI-Khobar over a period of eleven years. Results: We have noticed similarity in the frequency of the various symptoms with those reported in the literature except for the apparently more frequent hemarthrosis in our patients which mimics hemophilia. Conclusion : The spectrum of clinical presentations with Glanzmann's throm­bosthenia appears to be wide and the occurrence of the various symptoms var­ies. Moreover, some of the presenting features tend to mimic those of hemophilia, a situation which, in some cases, has resulted in unnecessary treatment with Factor VIII-containing blood components.


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